The Wynn laboratory is focused on the investigation of neonatal-specific innate immune cellular function and inflammatory signaling during sepsis as well as development of novel therapeutic immunomodulatory strategies aimed at improving sepsis outcomes.
We employ both preclinical mechanistic investigations in association with observational human studies to improve our understanding of the neonatal-specific host response to sepsis. We use a wide variety of molecular and genetic techniques to interrogate the immune response via in vivo, ex vivo, and in vitro approaches. Applications of our work include improving the accuracy of sepsis diagnostic methods, identification of prognostic and clinical stratification markers, and discovery of potential opportunities for translational interventions aimed at improving infection-related outcomes.
Guided by data, we developed and tested an objective, electronic health record (EHR)-automated, Neonatal Sequential Organ Failure Assessment (nSOFA) scoring system to predict mortality from LOS in premature, very low birth weight infants.
Our sepsis-targeted observational human neonatal studies have been performed in parallel with our mechanistic murine studies. We have three active, large-scale, human neonatal sepsis research projects:
We developed and validated the gold standard of murine neonatal sepsis modeling: the cecal slurry model of generalized peritonitis.
We are grateful to the agencies below that have provided support for our research program!
The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.
The purpose of the Fund is to provide grants for clinical, hypothesis-driven research that offers substantial promise for meaningful advances in the prevention, diagnosis and treatment of children’s diseases, particularly research that offers broad-based applications.
The mission of The Gerber Foundation, to enhance the quality of life of infants and young children in nutrition, care, and development, has remained the guiding beacon for Foundation giving throughout its history.
NICHD was founded in 1962 to investigate human development throughout the entire life process, with a focus on understanding disabilities and important events that occur during pregnancy.
The Department of Pediatrics consists of a dynamic and growing faculty dedicated to the highest quality patient care, research, and educational activity devoted to improving the health of children. This department is uniquely balanced, with almost exactly half of its budget derived from clinical activity and the other half from funded research