James L Wynn

James L Wynn, M.D.

Professor

Department: MD-PEDS-NEONATOLOGY
Business Phone: (352) 273-8985
Business Email: james.wynn@peds.ufl.edu

About James L Wynn

Dr. James Lawrence Wynn is a Professor of Pediatrics and Pathology, Immunology, and Experimental Medicine. He earned his medical degree and completed his clinical training in Pediatrics and Neonatal-Perinatal Medicine at the University of Florida (2002-2008). He served as faculty at Duke University and Vanderbilt University before joining UF Health in July of 2015. His research program centers on the investigation of sepsis in newborn and premature infants. He is a principle investigator on three active NIH R01 awards (2 clinical; 1 basic science). He has published 77 peer-reviewed manuscripts, reviews, book chapters, and editorials. He is an Associate Editor for Pediatric Research, has served as reviewer for the NIH, the Bill and Melinda Gates Foundation, USAID, and over 35 scientific journals. He has mentored over 20 trainees ranging from undergraduate to post-doctoral level.

Board Certifications

  • Neonatal – Perinatal Medicine
    American Board of Pediatrics

Clinical Profile

Specialties
  • Pediatrics
Subspecialties
  • Neonatal-Perinatal Medicine
Areas of Interest
  • Neonatal sepsis

Research Profile

The Wynn laboratory (http://wynn.research.pediatrics.med.ufl.edu) is focused on the investigation of neonatal-specific innate immune cellular function and inflammatory signaling during sepsis as well as development of novel therapeutic immunomodulatory strategies aimed at improving sepsis outcomes. Sepsis represents a significant clinical problem in the developmentally immature preterm neonate where attack rates may reach 60 percent with a 40 percent rate of death/major disability in developed countries. We employ both preclinical mechanistic investigations in association with observational human studies to improve our understanding of the neonatal-specific host response to sepsis. We use a wide variety of molecular and genetic techniques to interrogate the immune response via in vivo, ex vivo, and in vitro approaches. Applications of our work include improving the accuracy of sepsis diagnostic methods, identification of prognostic and clinical stratification markers, and discovery of potential opportunities for translational interventions aimed at improving infection-related outcomes.

Open Researcher and Contributor ID (ORCID)

0000-0001-7052-4836

Areas of Interest
  • Neonatal Sepsis

Publications

2019 Journal of visualized experiments : JoVE
2018 Archives of disease in childhood. Fetal and neonatal edition
2018 Journal of the Pediatric Infectious Diseases Society
2018 American journal of reproductive immunology (New York, N.Y. : 1989)
2018 American journal of reproductive immunology (New York, N.Y. : 1989)
2017 Archives of disease in childhood. Fetal and neonatal edition
2017 Translational research : the journal of laboratory and clinical medicine
2017 Journal of perinatology : official journal of the California Perinatal Association
2016 Archives of disease in childhood. Fetal and neonatal edition
2016 Proceedings of the National Academy of Sciences of the United States of America
2016 Current opinion in pediatrics
2015 Journal of immunology (Baltimore, Md. : 1950)
2013 Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
2013 Journal of perinatology : official journal of the California Perinatal Association
2013 American journal of perinatology

Grants

Aug 2019 ACTIVE
Salivary Diagnostics for Sepsis Screening in the Neonate
TUFTS MEDICAL CENTER · Principal Investigator
Jun 2018 ACTIVE
Modifiable Determinants of Mortality in Neonatal Sepsis
NATL INST OF HLTH NIGMS · Principal Investigator
Aug 2017 ACTIVE
Microfluidic Assessment of Clinical Outcomes in Preterm Newborns
NATL INST OF HLTH NICHD ·
Jul 2015 – Mar 2018
The Role of the Inflammasome in Neonatal Sepsis
NATL INST OF HLTH NIGMS · Principal Investigator

Education

Fellowship – Neonatal- Perinatal Medicine
2008 · University of Florida
Residency – Pediatrics
2005 · University of Florida
Internship – Pediatrics
2003 · University of Florida
Medical Degree
2002 · University of Florida

Contact Details

Phones:
Business:
(352) 273-8985
Emails: